2013 Jan - Cerebral Vasospasm Pharmacological Treatment: An Update
Siasios I, Kapsalaki EZ, Fountas KN.; Neurol Res Int. 2013;2013:571328. doi: 10.1155/2013/571328. Epub 2013 Jan 31.
Aneurysmal subarachnoid hemorrhage- (aSAH-) associated vasospasm constitutes a clinicopathological entity, in which reversible vasculopathy, impaired autoregulatory function, and hypovolemia take place, and lead to the reduction of cerebral perfusion and finally ischemia...
2013 Mar - How to Choose the Ideal Renal Replacement Therapy in Sepsis?
Filiponi TC, Durão MD Junior.; Shock. 2013 Mar 11. [Epub ahead of print]
Sepsis is the main cause of acute kidney injury (AKI) among individuals hospitalized in intensive care units. AKI is an independent risk factor for mortality, and its occurrence increase the complexity and cost of treatment...
2013 Feb - High-volume haemofiltration for sepsis [Review]
Borthwick EM, Hill CJ, Rabindranath KS, Maxwell AP, McAuley DF, Blackwood B.; Cochrane Database Syst Rev. 2013 Jan 31;1:CD008075
BACKGROUND: Severe sepsis and septic shock are leading causes of death in the intensive care unit (ICU). This is despite advances in the management of patients with severe sepsis and septic shock including early recognition, source control, timely and appropriate administration of antimicrobial agents, and goal directed haemodynamic, ventilatory and metabolic therapies. High-volume haemofiltration (HVHF) is a blood purification technique which may improve outcomes in critically ill patients with severe sepsis or septic shock. The technique of HVHF has evolved from renal replacement therapies used to treat acute kidney injury (AKI) in critically ill patients in the ICU.
2013 Feb - Decision Support for Hemodynamic Management: From Graphical Displays to Closed Loop Systems
Michard F.; Anesth Analg. 2013 Feb 28. [Epub ahead of print]
The way hemodynamic therapies are delivered today in anesthesia and critical care is suboptimal. Hemodynamic variables are not always understood correctly and used properly...
2013 Feb - High-frequency ventilation versus conventional ventilation for treatment of acute lung injury and acute respiratory distress syndrome [Review]
Sud S, Sud M, Friedrich JO, Wunsch H, Meade MO, Ferguson ND, Adhikari NK.; Cochrane Database Syst Rev. 2013 Feb 28;2:CD004085
BACKGROUND: High frequency oscillation is an alternative to conventional mechanical ventilation that is sometimes used to treat patients with acute respiratory distress syndrome, but effects on oxygenation, mortality and adverse clinical outcomes are uncertain. This review was originally published in 2004 and was updated in 2011.
2013 Feb - Hypothermia for neuroprotection in children after cardiopulmonary arrest [Review]
Scholefield B, Duncan H, Davies P, Gao Smith F, Khan K, Perkins GD, Morris K.; Cochrane Database Syst Rev. 2013 Feb 28;2:CD009442
BACKGROUND: Cardiopulmonary arrest in paediatric patients often results in death or survival with severe brain injury. Therapeutic hypothermia, lowering of the core body temperature to 32 °C to 34 °C, may reduce injury to the brain in the period after the circulation has been restored. This therapy has been effective in neonates with hypoxic ischaemic encephalopathy and adults after witnessed ventricular fibrillation cardiopulmonary arrest. The effect of therapeutic hypothermia after cardiopulmonary arrest in paediatric patients is unknown.
2013 Feb - Procalcitonin levels to guide antibiotic therapy in adults with non-microbiologically proven apparent severe sepsis: a randomised controlled trial
Annane D, Maxime V, Faller JP, Mezher C, Clec'h C, Martel P, Gonzales H, Feissel M, Cohen Y, Capellier G, Gharbi M, Nardi O.; BMJ Open. 2013 Feb 14;3(2).
OBJECTIVE: Some patients with the phenotype of severe sepsis may have no overt source of infection or identified pathogen. We investigated whether a procalcitonin-based algorithm influenced antibiotic use in patients with non-microbiologically proven apparent severe sepsis.
2013 Feb - Update on clinical trials for the prevention of acute kidney injury in patients undergoing cardiac surgery
Alsabbagh MM, Asmar A, Ejaz NI, Aiyer RK, Kambhampati G, Ejaz AA.; Am J Surg. 2013 Feb 11. [Epub ahead of print]
BACKGROUND: Effective therapeutic agents for the prevention and treatment of acute kidney injury (AKI) after cardiac surgery remain elusive despite the tremendous advances in surgical techniques, technology, and understanding of disease processes. Recent developments and their effect on the incidence of AKI after cardiac surgery are discussed.
2013 Feb - Hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin in patients with sepsis: systematic review with meta-analysis and trial sequential analysis
Haase N, Perner A, Hennings LI, Siegemund M, Lauridsen B, Wetterslev M, Wetterslev J.; BMJ. 2013 Feb 15;346:f839.
OBJECTIVE: To assess the effects of fluid therapy with hydroxyethyl starch 130/0.38-0.45 versus crystalloid or albumin on mortality, kidney injury, bleeding, and serious adverse events in patients with sepsis.
2013 Feb - Clinical effects of pulse high-volume hemofiltration on severe acute pancreatitis complicated with multiple organ dysfunction syndrome
Chu LP, Zhou JJ, Yu YF, Huang Y, Dong WX.; Ther Apher Dial. 2013 Feb;17(1):78-83.
To evaluate the effects of pulse high-volume hemofiltration (PHVHF) on severe acute pancreatitis (SAP) with multiple organ dysfunction syndrome (MODS)...
2012 Dec - Addition of intravenous beta(2)-agonists to inhaled beta(2)-agonists for acute asthma
Travers AH, Milan SJ, Jones AP, Camargo CA Jr, Rowe BH.; Cochrane Database Syst Rev. 2012 Dec 12;12:CD010179. doi: 10.1002/14651858.CD010179.
BACKGROUND: Inhaled beta-agonist therapy is central to the management of acute asthma. This review evaluates the benefit of an additional use of intravenous beta(2)-agonist agents.
2012 Dec - Intravenous beta(2)-agonists versus intravenous aminophylline for acute asthma
Travers AH, Jones AP, Camargo CA Jr, Milan SJ, Rowe BH.; Cochrane Database Syst Rev. 2012 Dec 12;12:CD010256. doi: 10.1002/14651858.CD010256.
BACKGROUND: Inhaled beta(2)-agonist therapy is central to the management of acute asthma. For rapid bronchodilation in severe cases, penetration of inhaled drug to the affected small conducting airway may be impeded, and the intravenous (IV) rather than inhaled administration of bronchodilators may provide an earlier response. IV beta(2)-agonist agents and IV aminophylline may also be considered as additional interventions in this setting and this review compares IV beta-agonist agents and IV aminophylline in the treatment of people with acute asthma.
2012 Dec - Industry sponsorship and research outcome
Lundh A, Sismondo S, Lexchin J, Busuioc OA, Bero L.; Cochrane Database Syst Rev. 2012 Dec 12;12:MR000033. doi: 10.1002/14651858.MR000033.pub2.
BACKGROUND: Clinical research affecting how doctors practice medicine is increasingly sponsored by companies that make drugs and medical devices. Previous systematic reviews have found that pharmaceutical industry sponsored studies are more often favorable to the sponsor's product compared with studies with other sources of sponsorship. This review is an update using more stringent methodology and also investigating sponsorship of device studies.
2013 Jan - Is the coverage of google scholar enough to be used alone for systematic reviews
Jean-François G, Laetitia R, Stefan D.; BMC Med Inform Decis Mak. 2013 Jan 9;13:7
Background: In searches for clinical trials and systematic reviews, it is said that Google Scholar (GS) should never be used in isolation, but in addition to PubMed, Cochrane, and other trusted sources of information. We therefore performed a study to assess the coverage of GS specifically for the studies included in systematic reviews and evaluate if GS was sensitive enough to be used alone for systematic reviews.
2012 Dec - Impact of a high loading dose of atorvastatin on contrast-induced acute kidney injury
Quintavalle C, Fiore D, De Micco F, Visconti G, Focaccio A, Golia B, Ricciardelli B, Donnarumma E, Bianco A, Zabatta MA, Troncone G, Colombo A, Briguori C, Condorelli G.; Circulation. 2012 Dec 18;126(25):3008-16.
BACKGROUND: The role of statins in the prevention of contrast-induced acute kidney injury (CIAKI) is controversial.
2013 Jan - A randomised comparison of InnoScope and Macintosh laryngoscope in simulated difficult tracheal intubation in manikins.
Fong AW, Lam KC, Cheng BC, Lam KK, Chan MT.; Anaesthesia. 2013 Feb;68(2):167-74.
We conducted a crossover randomised study to evaluate the performance of a novel optical stylet, the InnoScope, for tracheal intubation in simulated normal and difficult airways.
2012 Sep - Unfractionated heparin versus low molecular weight heparin for avoiding heparin-induced thrombocytopenia in postoperative patients
Junqueira DR, Perini E, Penholati RR, Carvalho MG.; Cochrane Database Syst Rev. 2012 Sep 12;9:CD007557
BACKGROUND: Heparin-induced thrombocytopenia (HIT) is an adverse drug reaction presenting as a prothrombotic disorder related to antibody-mediated platelet activation. It is a poorly understood paradoxical immune reaction resulting in thrombin generation in vivo, which leads to a hypercoagulable state and the potential to initiate venous or arterial thrombosis.
2012 Sep - N-acetylcysteine for sepsis and systemic inflammatory response in adults
Szakmany T, Hauser B, Radermacher P.; Cochrane Database Syst Rev. 2012 Sep 12;9:CD006616.
BACKGROUND: Death is common in systemic inflammatory response syndrome (SIRS) or sepsis-induced multisystem organ failure and it has been thought that antioxidants such as N-acetylcysteine could be beneficial.
2012 Nov - Efficacy of High-dose Nebulized Colistin in Ventilator-associated Pneumonia Caused by Multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii.
Lu Q, Luo R, Bodin L, Yang J, Zahr N, Aubry A, Golmard JL, Rouby JJ; the Nebulized Antibiotics Study Group.; Anesthesiology. 2012 Nov 4. [Epub ahead of print]
Background: Colistin often remains the only active agent against multidrug-resistant Gram-negative pathogens. The aim of the study was to assess efficacy of nebulized colistin for treating ventilator-associated pneumonia (VAP) caused by multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii.
2012 Nov - Aerosolized Antibiotics for Ventilator-associated Pneumonia: Lessons from Experimental Studies
Rouby JJ, Bouhemad B, Monsel A, Brisson H, Arbelot C, Lu Q; and the Nebulized Antibiotics Study Group.; Anesthesiology. 2012 Nov 6. [Epub ahead of print]
The aim of this review is to perform a critical analysis of experimental studies on aerosolized antibiotics and draw lessons for clinical use in patients with ventilator-associated pneumonia. Ultrasonic or vibrating plate nebulizers should be preferred to jet nebulizers....