2012 Jul - Treatment limitations at admission to intensive care units in Australia and New Zealand: Prevalence, outcomes, and resource use
Godfrey G, Pilcher D, Hilton A, Bailey M, Hodgson CL, Bellomo R.; Crit Care Med. 2012 Jul;40(7):2082-2089.
Background: Previous studies have addressed patients in whom treatment is withheld or withdrawn after a period of intensive care unit management. However, no studies have investigated the epidemiology of patients with treatment limitations in place at the time of intensive care unit admission.
2012 Jul - Diagnostic accuracy of insulin-like growth factor binding protein-1 for amniotic fluid embolism
Legrand M, Rossignol M, Dreux S, Luton D, Ventré C, Barranger E, Laribi S, Payen D, Muller F.; Crit Care Med. 2012 Jul;40(7):2059-2063.
Objective: To test whether serum insulin-like growth factor binding protein-1 could be used as a biomarker of amniotic fluid passage into the maternal circulation.
2012 Jul - The determinants of hospital mortality among patients with septic shock receiving appropriate initial antibiotic treatment
Labelle A, Juang P, Reichley R, Micek S, Hoffmann J, Hoban A, Hampton N, Kollef M.; Crit Care Med. 2012 Jul;40(7):2016-21.
Objective: To identify the determinants of hospital mortality among patients with septic shock receiving appropriate initial antibiotic treatment.
2012 Jun - Delirium screening in critically ill patients: A systematic review and meta-analysis [Review]
Neto AS, Nassar AP Jr, Cardoso SO, Manetta JA, Pereira VG, Espósito DC, Damasceno MC, Slooter AJ.; Crit Care Med. 2012 Jun;40(6):1946-51.
Objective: Despite its frequency and impact, delirium in critically ill patients is poorly recognized. Our aim was to systematically review the accuracy of delirium screening instruments in critically ill patients.
2012 Jun - Tight glycemic control increases metabolic distress in traumatic brain injury: A randomized controlled within-subjects trial
Vespa P, McArthur DL, Stein N, Huang SC, Shao W, Filippou M, Etchepare M, Glenn T, Hovda DA.; Crit Care Med. 2012 Jun;40(6):1923-9.
Objective: To determine the effects of tight glycemic control on brain metabolism after traumatic brain injury using brain positron emission tomography and microdialysis.
2012 Jun - Neuromuscular blocking agent administration for emergent tracheal intubation is associated with decreased prevalence of procedure-related complications
Wilcox SR, Bittner EA, Elmer J, Seigel TA, Nguyen NT, Dhillon A, Eikermann M, Schmidt U.; Crit Care Med. 2012 Jun;40(6):1808-1813.
Background: Emergent intubation is associated with a high rate of complications. Neuromuscular blocking agents are routinely used in the operating room and emergency department to facilitate intubation. However, use of neuromuscular blocking agents during emergent airway management outside of the operating room and emergency department is controversial. We hypothesized that the use of neuromuscular blocking agents is associated with a decreased prevalence of hypoxemia and reduced rate of procedure-related complications.
2012 Jun - A double-blind, randomized clinical trial comparing soybean oil-based versus olive oil-based lipid emulsions in adult medical-surgical intensive care unit patients requiring parenteral nutrition
Umpierrez GE, Spiegelman R, Zhao V, Smiley DD, Pinzon I, Griffith DP, Peng L, Morris T, Luo M, Garcia H, Thomas C, Newton CA, Ziegler TR.; Crit Care Med. 2012 Jun;40(6):1792-8.
Objective: Parenteral nutrition has been associated with metabolic and infectious complications in intensive care unit patients. The underlying mechanism for the high risk of complications is not known but may relate to the proinflammatory effects of soybean oil–based lipid emulsions, the only Food and Drug Administration–approved lipid formulation for clinical use.
2012 Jun - Acetyl salicylic acid usage and mortality in critically ill patients with the systemic inflammatory response syndrome and sepsis
Eisen DP, Reid D, McBryde ES.; Crit Care Med. 2012 Jun;40(6):1761-7.
Objective: Low doses of acetyl salicylic acid, acting through 15-epi-lipoxin A4, have been shown to be anti-inflammatory in human studies. The manifold effects of acetyl salicylic acid on human physiology potentially may benefit patients with the systemic inflammatory response syndrome after sepsis or tissue trauma. We sought to determine whether acetyl salicylic acid administration at the time of development of systemic inflammatory response syndrome is associated with reduced mortality.
2012 Jun - Neurally adjusted ventilatory assist improves patient-ventilator interaction during postextubation prophylactic noninvasive ventilation
Schmidt M, Dres M, Raux M, Deslandes-Boutmy E, Kindler F, Mayaux J, Similowski T, Demoule A.; Crit Care Med. 2012 Jun;40(6):1738-1744.
Objectives: To compare the respective impact of pressure support ventilation and naturally adjusted ventilatory assist, with and without a noninvasive mechanical ventilation algorithm, on patient–ventilator interaction.
2012 Jun - Mild therapeutic hypothermia in cardiogenic shock syndrome
Zobel C, Adler C, Kranz A, Seck C, Pfister R, Hellmich M, Kochanek M, Reuter H.; Crit Care Med. 2012 Jun;40(6):1715-23.
Objective: Mortality in patients with cardiogenic shock after out-of-hospital cardiac arrest remains high despite advances in resuscitation and early revascularization strategies. Recent studies suggest a reduced mortality in survivors of cardiac arrest subjected to mild therapeutic hypothermia, but the underlying mechanisms are not yet clear. Because positive hemodynamic effects of mild therapeutic hypothermia have been suggested, we aimed at testing the hypothesis that patients in cardiogenic shock might benefit from mild therapeutic hypothermia.
2012 Jun - Dressing disruption is a major risk factor for catheter-related infections
Timsit JF, Bouadma L, Ruckly S, Schwebel C, Garrouste-Orgeas M, Bronchard R, Calvino-Gunther S, Laupland K, Adrie C, Thuong M, Herault MC, Pease S, Arrault X, Lucet JC.; Crit Care Med. 2012 Jun;40(6):1707-1714.
OBJECTIVE: Major catheter-related infection includes catheter-related bloodstream infections and clinical sepsis without bloodstream infection resolving after catheter removal with a positive quantitative tip culture. Insertion site dressings are a major mean to reduce catheter infections by the extraluminal route. However, the importance of dressing disruptions in the occurrence of major catheter-related infection has never been studied in a large cohort of patients.
2012 May - Nutritional practices and their relationship to clinical outcomes in critically ill children-An international multicenter cohort study
Mehta NM, Bechard LJ, Cahill N, Wang M, Day A, Duggan CP, Heyland DK.; Crit Care Med. 2012 May 4. [Epub ahead of print]
OBJECTIVES: To examine factors influencing the adequacy of energy and protein intake in the pediatric intensive care unit and to describe their relationship to clinical outcomes in mechanically ventilated children.
2012 May - Variation in use of intensive care for adults with diabetic ketoacidosis
Gershengorn HB, Iwashyna TJ, Cooke CR, Scales DC, Kahn JM, Wunsch H.; Crit Care Med. 2012 May 4. [Epub ahead of print]
OBJECTIVE: Intensive care unit beds are limited, yet few guidelines exist for triage of patients to the intensive care unit, especially patients at low risk for mortality. The frequency with which low-risk patients are admitted to intensive care units in different hospitals is unknown. Our objective was to assess variation in the use of intensive care for patients with diabetic ketoacidosis, a common condition with a low risk of mortality.
2012 May - A systematic review and meta-analysis of clinical trials of thyroid hormone administration to brain dead potential organ donors
Macdonald PS, Aneman A, Bhonagiri D, Jones D, O'Callaghan G, Silvester W, Watson A, Dobb G.; Crit Care Med. 2012 May;40(5):1635-44.
Objectives: To review all published clinical studies of thyroid hormone administration to brain-dead potential organ donors.
2012 May - Occurrence and impact of intracranial pressure elevation during treatment of severe intraventricular hemorrhage
Ziai WC, Melnychuk E, Thompson CB, Awad I, Lane K, Hanley DF.; Crit Care Med. 2012 May;40(5):1601-8.
Objectives: Elevated intracranial pressure is one of the proposed mechanisms leading to poor outcomes in patients with intraventricular hemorrhage. We sought to characterize the occurrence and significance of intracranial hypertension in severe intraventricular hemorrhage requiring extraventricular drainage.