2012 Jan - Rationing in the intensive care unit: To disclose or disguise?
Young MJ, Brown SE, Truog RD, Halpern SD.; Crit Care Med. 2012 Jan;40(1):261-266.
Introduction: Growing pressures to ration intensive care unit beds and services pose novel challenges to clinicians. Whereas the question of how to allocate scarce intensive care unit resources has received much attention, the question of whether to disclose these decisions to patients and surrogates has not been explored.
2012 Jan - Cardiac and central vascular functional alterations in the acute phase of aneurysmal subarachnoid hemorrhage
Papanikolaou J, Makris D, Karakitsos D, Saranteas T, Karabinis A, Kostopanagiotou G, Zakynthinos E.; Crit Care Med. 2012 Jan;40(1):223-32.
Objectives: To investigate aortic functional alterations in the acute phase of aneurysmal subarachnoid hemorrhage and to evaluate the relationship between potential cardiovascular alterations and delayed cerebral infarctions or poor Glasgow Outcome Scale score at discharge from critical care unit.
2012 Jan - Osmolar therapy in pediatric traumatic brain injury [Review]
Bennett TD, Statler KD, Korgenski EK, Bratton SL.; Crit Care Med. 2012 Jan;40(1):208-15.
Objectives: To describe patterns of use for mannitol and hypertonic saline in children with traumatic brain injury, to evaluate any potential associations between hypertonic saline and mannitol use and patient demographic, injury, and treatment hospital characteristics, and to determine whether the 2003 guidelines for severe pediatric traumatic brain injury impacted clinical practice regarding osmolar therapy.
2012 Jan Efficacy and safety of first-line rituximab in severe, acquired thrombotic thrombocytopenic purpura with a suboptimal response to plasma exchange. Experience of the French Thrombotic Microangiopathies Reference Center
Froissart A, Buffet M, Veyradier A, Poullin P, Provôt F, Malot S, Schwarzinger M, Galicier L, Vanhille P, Vernant JP, Bordessoule D, Guidet B, Azoulay E, Mariotte E, Rondeau E, Mira JP, Wynckel A, Clabault K, Choukroun G, Presne C, Pourrat J, Hamidou M, Coppo P.; Crit Care Med. 2012 Jan;40(1):104-111.
Objective: To assess the efficacy and safety of rituximab in adults responding poorly to standard treatment for severe autoimmune thrombotic thrombocytopenic purpura.
2012 Jan - A randomized trial of recombinant human granulocyte-macrophage colony stimulating factor for patients with acute lung injury
Paine R 3rd, Standiford TJ, Dechert RE, Moss M, Martin GS, Rosenberg AL, Thannickal VJ, Burnham EL, Brown MB, Hyzy RC.; Crit Care Med. 2012 Jan;40(1):90-97.
Rationale: Despite recent advances in critical care and ventilator management, acute lung injury and acute respiratory distress syndrome continue to cause significant morbidity and mortality. Granulocyte-macrophage colony stimulating factor may be beneficial for patients with acute respiratory distress syndrome.
2012 Jan- Delayed enteral feeding impairs intestinal carbohydrate absorption in critically ill patients
Nguyen NQ, Besanko LK, Burgstad C, Bellon M, Holloway RH, Chapman M, Horowitz M, Fraser RJ.;Crit Care Med. 2012 Jan;40(1):50-4.
Objectives: Delay in initiating enteral nutrition has been reported to disrupt intestinal mucosal integrity in animals and to prolong the duration of mechanical ventilation in humans. However, its impact on intestinal absorptive function in critically ill patients is unknown. The aim of this study was to examine the impact of delayed enteral nutrition on small intestinal absorption of 3-O-methyl-glucose.
2012 Jan - Cytomegalovirus serostatus and outcome in nonimmunocompromised critically ill patients
De Vlieger G, Meersseman W, Lagrou K, Wouters P, Wilmer A, Peetermans WE, Van den Berghe G, Van Wijngaerden E.; Crit Care Med. 2012 Jan;40(1):36-42.
Objective: The impact of cytomegalovirus reactivation during critical illness remains unclear and studies investigating prophylaxis in cytomegalovirus seropositive patients are being considered. This study investigates the association between cytomegalovirus seropositivity and outcome in a large population of nonimmunocompromised critically ill patients.
2012 Jan - Corticosteroid after etomidate in critically ill patients: A randomized controlled trial
Payen JF, Dupuis C, Trouve-Buisson T, Vinclair M, Broux C, Bouzat P, Genty C, Monneret D, Faure P, Chabre O, Bosson JL.; Crit Care Med. 2012 Jan;40(1):29-35.
Objective: To investigate the effects of moderate-dose hydrocortisone on hemodynamic status in critically ill patients throughout the period of etomidate-related adrenal insufficiency.
2012 Jan -Economic evaluation of chlorhexidine-impregnated sponges for preventing catheter-related infections in critically ill adults in the Dressing Study
Schwebel C, Lucet JC, Vesin A, Arrault X, Calvino-Gunther S, Bouadma L, Timsit JF.; Crit Care Med. 2012 Jan;40(1):11-7.
Background: The randomized two-way factorial Dressing Study (1,636 patients, 28,931 catheter days) showed that a chlorhexidine-impregnated sponge decreased the incidence of major catheter-related infections from 1.4‰ to 0.6‰ catheter days, and that scheduled dressing changes every 7 days was not inferior to scheduled changes every 3 days. Here, we assessed the cost benefits of chlorhexidine-impregnated sponge use.
2011 Jun - Reversible brain death after cardiopulmonary arrest and induced hypothermia
Objective: To describe a patient with transient reversal of findings of brain death after cardiopulmonary arrest and attempted therapeutic hypothermia.