2010 Mar - Passive leg raising is predictive of fluid responsiveness in spontaneously breathing patients with severe sepsis or acute pancreatitis
Préau, Sébastien; Saulnier, Fabienne; Dewavrin, Florent; Durocher, Alain; Chagnon, Jean-Luc; Critical Care Medicine. 38(3):819-825, March 2010.
Objective: Rapid fluid loading is standard treatment for hypovolemia. Because volume expansion does not always improve hemodynamic status, predictive parameters of fluid responsiveness are needed. Passive leg raising is a reversible maneuver that mimics rapid volume expansion. Passive leg raising-induced changes in stroke volume and its surrogates are reliable predictive indices of volume expansion responsiveness for mechanically ventilated patients. We hypothesized that the hemodynamic response to passive leg raising indicates fluid responsiveness in nonintubated patients without mechanical ventilation.
2010 Mar - A multifaceted program to prevent ventilator-associated pneumonia: Impact on compliance with preventive measures
Bouadma, Lila; Mourvillier, Bruno; Deiler, Véronique; Le Corre, Bertrand; Lolom, Isabelle; Régnier, Bernard; Wolff, Michel; Lucet, Jean-Christophe; Critical Care Medicine. 38(3):789-796, March 2010.
Objective: To determine the effect of a 2-yr multifaceted program aimed at preventing ventilator-acquired pneumonia on compliance with eight targeted preventive measures.
2010 Feb - A cost-minimization analysis of dexmedetomidine compared with midazolam for long-term sedation in the intensive care unit
OBJECTIVE: To compare the intensive care unit costs and determine factors influencing these costs in mechanically ventilated patients randomized to dexmedetomidine or midazolam by continuous infusion. DESIGN: Cost minimization analysis of a double-blind, multicenter clinical trial randomizing patients 2:1 to receive dexmedetomidine or midazolam from the institutional perspective.
2010 Feb - Intensive care unit alarms--how many do we need?
Siebig S, Kuhls S, Imhoff M, Gather U, Schölmerich J, Wrede CE.; Crit Care Med. 2010 Feb;38(2):451-6.
OBJECTIVE: To validate cardiovascular alarms in critically ill patients in an experimental setting by generating a database of physiologic data and clinical alarm annotations, and report the current rate of alarms and their clinical validity. Currently, monitoring of physiologic parameters in critically ill patients is performed by alarm systems with high sensitivity, but low specificity. As a consequence, a multitude of alarms with potentially negative impact on the quality of care is generated.
2010 Feb - Is the evolving management of intra-abdominal hypertension and abdominal compartment syndrome improving survival?
Cheatham ML, Safcsak K.; Crit Care Med. 2010 Feb;38(2):402-7.
OBJECTIVE: The diagnosis and management of intra-abdominal hypertension and abdominal compartment syndrome have changed significantly over the past decade with improved understanding of the pathophysiology and appropriate treatment of these disease processes. Serial intra-abdominal pressure measurements, nonoperative pressure-reducing interventions, and early abdominal decompression for refractory intra-abdominal hypertension or abdominal compartment syndrome are all key elements of this evolving strategy.
2010 Feb - Extracorporeal membrane oxygenation for the support of infants, children, and young adults with acute myocarditis: a review of the Extracorporeal Life Support Organization registry.
Rajagopal SK, Almond CS, Laussen PC, Rycus PT, Wypij D, Thiagarajan RR.; Crit Care Med. 2010 Feb;38(2):382-7.
OBJECTIVE: To describe survival outcomes for pediatric patients supported with extracorporeal membrane oxygenation for severe myocarditis and identify risk factors for in-hospital mortality.
2009 Dec - Clinical practice guideline: red blood cell transfusion in adult trauma and critical care.
Comment in: · Crit Care Med. 2009 Dec;37(12):3124-3157.
OBJECTIVE: To develop a clinical practice guideline for red blood cell transfusion in adult trauma and critical care. DESIGN: Meetings, teleconferences and electronic-based communication to achieve grading of the published evidence, discussion and consensus among the entire committee members.
2010 Jan - Intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP SHOCK Trial for attenuation of multiorgan dysfunction syndrome.
Prondzinsky R, Lemm H, Swyter M, Wegener N, Unverzagt S, Carter JM, Russ M, Schlitt A, Buerke U, Christoph A, Schmidt H, Winkler M, Thiery J, Werdan K, Buerke M.; Crit Care Med. 2010 Jan;38(1):152-60.
OBJECTIVE: Patients undergoing percutaneous coronary intervention (PCI) for acute myocardial infarction with cardiogenic shock (CS) are often treated with intra-aortic balloon pump counterpulsation (IABP), even though the evidence to support this is limited. We determined whether IABP as an addition to PCI-centered therapy ameliorates multiorgan dysfunction syndrome (MODS) in patients with acute myocardial infarction complicated by CS.
2010 Jan - A multicenter, randomized trial of noninvasive ventilation with helium-oxygen mixture in exacerbations of chronic obstructive lung disease.
Maggiore SM, Richard JC, Abroug F, Diehl JL, Antonelli M, Sauder P, Mancebo J, Ferrer M, Lellouche F, Lecourt L, Beduneau G, Brochard L.; Crit Care Med. 2010 Jan;38(1):145-51.
OBJECTIVE: To assess the effect of a helium-oxygen mixture on intubation rate and clinical outcomes during noninvasive ventilation in acute exacerbation of chronic obstructive pulmonary disease.
209 Dec - Nonventilatory strategies for patients with life-threatening 2009 H1N1 influenza and severe respiratory failure.
Napolitano LM, Park PK, Raghavendran K, Bartlett RH.; Crit Care Med. 2009 Dec 23.
Severe respiratory failure (including acute lung injury and acute respiratory distress syndrome) caused by 2009 H1N1 influenza infection has been reported worldwide. Refractory hypoxemia is a common finding in these patients and can be challenging to manage. This review focuses on nonventilatory strategies in the advanced treatment of severe respiratory failure and refractory hypoxemia such as that seen in patients with severe acute respiratory distress syndrome attributable to 2009 H1N1 influenza.
2010 Jan - Effect of vancomycin plus rifampicin in the treatment of nosocomial methicillin-resistant Staphylococcus aureus pneumonia
Jung, Young Ju; Koh, Younsuck; Hong, Sang-Bum; Chung, Joo Won; Choi, Sang Ho; Kim, Nam Joong; Kim, Mi-Na; Choi, Ik Su; Han, Song Yi; Kim, Won-Dong; Yun, Sung-Cheol; Lim, Chae-Man; Critical Care Medicine. 38(1):175-180, January 2010.
Objective: To investigate whether adding rifampicin to vancomycin could cure more patients with nosocomial methicillin-resistant Staphylococcus aureus pneumonia compared with vancomycin-only.
2010 Jan - Antiplatelet drugs and outcome in mixed admissions to an intensive care unit.
Winning J, Neumann J, Kohl M, Claus RA, Reinhart K, Bauer M, Lösche W.; Crit Care Med. 2010 Jan;38(1):32-37.
OBJECTIVE:: Platelet activation has been implicated in microvascular thrombosis and organ failure. We tested the hypothesis that antiplatelet drugs favorably affect outcome in patients nonelectively admitted to an intensive care unit.
2010 Jan - Characteristics and outcomes of patients with cancer requiring admission to intensive care units: A prospective multicenter study.
Soares M, Caruso P, Silva E, Teles JM, Lobo SM, Friedman G, Dal Pizzol F, Mello PV, Bozza FA, Silva UV, Torelly AP, Knibel MF, Rezende E, Netto JJ, Piras C, Castro A, Ferreira BS, Réa-Neto A, Olmedo PB, Salluh JI; on behalf of the Brazilian Research in Intensive Care Network (BRICNet).; Crit Care Med. 2010 Jan;38(1):9-15.
OBJECTIVE:: To evaluate the characteristics and outcomes of patients with cancer admitted to several intensive care units. Knowledge on patients with cancer requiring intensive care is mostly restricted to single-center studies.
2009 Dec - Long-term survival in older critically ill patients with acute ischemic stroke.
Golestanian E, Liou JI, Smith MA.; Crit Care Med. 2009 Dec;37(12):3107-13.
OBJECTIVES: To compare survival in older patients with acute ischemic stroke admitted to intensive care units (ICUs) with those not requiring ICU care and to assess the impact of mechanical ventilation (MV) and percutaneous gastrostomy tubes (PEG) on long-term mortality.
2009 Dec- Propofol infusion syndrome in patients with refractory status epilepticus: an 11-year clinical experience.
Iyer VN, Hoel R, Rabinstein AA.; Crit Care Med. 2009 Dec;37(12):3024-30.
OBJECTIVES: Propofol is a sedative, anesthetic, and antiepileptic agent that is frequently used in patients with refractory status epilepticus. Propofol infusion syndrome is a feared complication of propofol use, especially at high infusion rates for prolonged periods. The present study describes the use of propofol and its associated complications in patients with refractory status epilepticus.
2009 Dec - Hyperglycemia-related mortality in critically ill patients varies with admission diagnosis.
Falciglia M, Freyberg RW, Almenoff PL, D'Alessio DA, Render ML.; Crit Care Med. 2009 Dec;37(12):3001-9.
OBJECTIVES: Hyperglycemia during critical illness is common and is associated with increased mortality. Intensive insulin therapy has improved outcomes in some, but not all, intervention trials. It is unclear whether the benefits of treatment differ among specific patient populations. The purpose of the study was to determine the association between hyperglycemia and risk- adjusted mortality in critically ill patients and in separate groups stratified by admission diagnosis.
2009 Dec - Active surface cooling protocol to induce mild therapeutic hypothermia after out-of-hospital cardiac arrest: a retrospective before-and-after comparison in a single hospital.
Don CW, Longstreth WT Jr, Maynard C, Olsufka M, Nichol G, Ray T, Kupchik N, Deem S, Copass MK, Cobb LA, Kim F.; Crit Care Med. 2009 Dec;37(12):3062-9.
OBJECTIVE: To evaluate whether implementation of a therapeutic hypothermia protocol on arrival in a community hospital improved survival and neurologic outcomes in patients initially found to have ventricular fibrillation, pulseless electrical activity, or asystole, and then successfully resuscitated from out-of-hospital cardiac arrest.
2009 Oct - Ultrasound localization of central vein catheter and detection of postprocedural pneumothorax: An alternative to chest radiography
Vezzani A, Brusasco C, Palermo S, Launo C, Mergoni M, Corradi F.: Crit Care Med. 2009 Oct 12.
OBJECTIVE:: To determine the usefulness of ultrasound to evaluate central venous catheter misplacements and detection of pneumothorax, thus obviating postprocedural radiograph. After the insertion of a central venous catheter, chest radiograph is usually obtained to ensure correct positioning of the catheter tip and detect postprocedural complications.
2009 Oct - Metabolic acidosis in patients with severe sepsis and septic shock: a longitudinal quantitative study.
Noritomi DT, Soriano FG, Kellum JA, Cappi SB, Biselli PJ, Libório AB, Park M.; Crit Care Med. 2009 Oct;37(10):2733-9.
OBJECTIVE: To describe the composition of metabolic acidosis in patients with severe sepsis and septic shock at intensive care unit admission and throughout the first 5 days of intensive care unit stay.
2009 Nov - Selection of intensive care unit admission criteria for patients aged 80 years and over and compliance of emergency and intensive care unit physicians with the selected criteria: An observational, multicenter, prospective study.
Garrouste-Orgeas M, Boumendil A, Pateron D, Aergerter P, Somme D, Simon T, Guidet B; ICE-CUB Group.; Crit Care Med. 2009 Nov;37(11):2919-28.
OBJECTIVE: To describe intensive care unit referral decisions by emergency room physicians in patients aged > or =80 yrs.
DESIGN: Prospective, observational cohort study of patients aged > or =80 yrs who were triaged in the emergency room, using a list of intensive care unit admission criteria selected by emergency physicians among 76 preliminary criteria adapted from the 1999 Society of Critical Care Medicine guidelines. The Delphi method was used to select the criteria.